1hf2

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{{STRUCTURE_1hf2| PDB=1hf2 | SCENE= }}
{{STRUCTURE_1hf2| PDB=1hf2 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE BACTERIAL CELL-DIVISION INHIBITOR MINC FROM T. MARITIMA'''
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===CRYSTAL STRUCTURE OF THE BACTERIAL CELL-DIVISION INHIBITOR MINC FROM T. MARITIMA===
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==Overview==
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Bacterial cell division requires accurate selection of the middle of the cell, where the bacterial tubulin homologue FtsZ polymerizes into a ring structure. In Escherichia coli, site selection is dependent on MinC, MinD and MINE: MinC acts, with MinD, to inhibit division at sites other than the midcell by directly interacting with FTSZ: Here we report the crystal structure to 2.2 A of MinC from Thermotoga maritima. MinC consists of two domains separated by a short linker. The C-terminal domain is a right-handed beta-helix and is involved in dimer formation. The crystals contain two different MinC dimers, demonstrating flexibility in the linker region. The two-domain architecture and dimerization of MinC can be rationalized with a model of cell division inhibition. MinC does not act like SulA, which affects the GTPase activity of FtsZ, and the model can explain how MinC would select for the FtsZ polymer rather than the monomer.
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The line below this paragraph, {{ABSTRACT_PUBMED_11350934}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11350934 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11350934}}
==About this Structure==
==About this Structure==
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[[Category: Ftsz]]
[[Category: Ftsz]]
[[Category: Septum]]
[[Category: Septum]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:47:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:06:03 2008''

Revision as of 05:06, 1 July 2008

Image:1hf2.png

Template:STRUCTURE 1hf2

CRYSTAL STRUCTURE OF THE BACTERIAL CELL-DIVISION INHIBITOR MINC FROM T. MARITIMA

Template:ABSTRACT PUBMED 11350934

About this Structure

1HF2 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of the bacterial cell division inhibitor MinC., Cordell SC, Anderson RE, Lowe J, EMBO J. 2001 May 15;20(10):2454-61. PMID:11350934

Page seeded by OCA on Tue Jul 1 08:06:03 2008

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