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1hh4

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{{STRUCTURE_1hh4| PDB=1hh4 | SCENE= }}
{{STRUCTURE_1hh4| PDB=1hh4 | SCENE= }}
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'''RAC1-RHOGDI COMPLEX INVOLVED IN NADPH OXIDASE ACTIVATION'''
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===RAC1-RHOGDI COMPLEX INVOLVED IN NADPH OXIDASE ACTIVATION===
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==Overview==
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A heterodimer of prenylated Rac1 and Rho GDP dissociation inhibitor was purified and found to be competent in NADPH oxidase activation. Small angle neutron scattering experiments confirmed a 1:1 stoichiometry. The crystal structure of the Rac1-RhoGDI complex was determined at 2.7 A resolution. In this complex in which Rac1 is bound to GDP, the switch I region of Rac1 is in the GDP conformation whereas the switch II region resembles that of a GTP-bound GTPase. Two types of interaction between RhoGTPases and RhoGDI were investigated. The lipid-protein interaction between the geranylgeranyl moiety of Rac1 and RhoGDI resulted in numerous structural changes in the core of RhoGDI. The interactions between Rac1 and RhoGDI occur through hydrogen bonds which involve a number of residues of Rac1, namely, Tyr64(Rac), Arg66(Rac), His103(Rac), and His104(Rac), conserved within the Rho family and localized in the switch II region or in its close neighborhood. Moreover, in the switch II region of Rac1, hydrophobic interactions involving Leu67(Rac) and Leu70(Rac) contribute to the stability of the Rac1-RhoGDI complex. Inhibition of the GDP-GTP exchange in Rac1 upon binding to RhoGDI partly results from interaction of Thr35(Rac) with Asp45(GDI). In the Rac1-RhoGDI complex, the accessibility of the effector loops of Rac1 probably accounts for the ability of the Rac1-RhoGDI complex to activate the NADPH oxidase.
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{{ABSTRACT_PUBMED_11513578}}
==About this Structure==
==About this Structure==
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[[Category: Prenylation]]
[[Category: Prenylation]]
[[Category: Small g protein]]
[[Category: Small g protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:10:44 2008''

Revision as of 05:10, 1 July 2008

Image:1hh4.png

Template:STRUCTURE 1hh4

RAC1-RHOGDI COMPLEX INVOLVED IN NADPH OXIDASE ACTIVATION

Template:ABSTRACT PUBMED 11513578

About this Structure

1HH4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation., Grizot S, Faure J, Fieschi F, Vignais PV, Dagher MC, Pebay-Peyroula E, Biochemistry. 2001 Aug 28;40(34):10007-13. PMID:11513578

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