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1hhp

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[[Image:1hhp.gif|left|200px]]
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{{STRUCTURE_1hhp| PDB=1hhp | SCENE= }}
{{STRUCTURE_1hhp| PDB=1hhp | SCENE= }}
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'''THE THREE-DIMENSIONAL STRUCTURE OF THE ASPARTYL PROTEASE FROM THE HIV-1 ISOLATE BRU'''
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===THE THREE-DIMENSIONAL STRUCTURE OF THE ASPARTYL PROTEASE FROM THE HIV-1 ISOLATE BRU===
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==Overview==
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The crystal structure of the aspartyl protease encoded by the gene pol of the human immunodeficiency virus (HIV-1, isolate BRU) has been determined to 2.7 A resolution. The enzyme, expressed as an insoluble denatured polypeptide in inclusion bodies of Escherichia coli has been renatured and crystallized. It differs by several amino acid replacements from the homologous enzymes of other HIV-1 isolates. A superposition of the C alpha-backbone of the BRU protease with that of the SF2 protease gives a roots mean square positional difference of 0.45 A. Thus, neither the denaturation/renaturation process nor the amino acid replacements have a noticeable effect on the three-dimensional structure of the BRU protease or on the detailed conformation of the catalytic site, which is very similar to that of other aspartyl proteases.
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(as it appears on PubMed at http://www.pubmed.gov), where 1799632 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1799632}}
==About this Structure==
==About this Structure==
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[[Category: Alzari, P M.]]
[[Category: Alzari, P M.]]
[[Category: Spinelli, S.]]
[[Category: Spinelli, S.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:51:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:11:55 2008''

Revision as of 05:12, 1 July 2008

Image:1hhp.png

Template:STRUCTURE 1hhp

THE THREE-DIMENSIONAL STRUCTURE OF THE ASPARTYL PROTEASE FROM THE HIV-1 ISOLATE BRU

Template:ABSTRACT PUBMED 1799632

About this Structure

1HHP is a Single protein structure of sequence from Human immunodeficiency virus type 1 (isolate bru). Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU., Spinelli S, Liu QZ, Alzari PM, Hirel PH, Poljak RJ, Biochimie. 1991 Nov;73(11):1391-6. PMID:1799632

Page seeded by OCA on Tue Jul 1 08:11:55 2008

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