1hhu

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{{Seed}}
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{{STRUCTURE_1hhu| PDB=1hhu | SCENE= }}
{{STRUCTURE_1hhu| PDB=1hhu | SCENE= }}
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'''BALHIMYCIN IN COMPLEX WITH D-ALA-D-ALA'''
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===BALHIMYCIN IN COMPLEX WITH D-ALA-D-ALA===
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==Overview==
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The vancomycin-related antibiotics balhimycin and degluco-balhimycin have been crystallized in complexes with di-, tri- and pentapeptides that emulate bacterial cell-wall precursors, and four structures determined at atomic resolution (&lt;1 A). In addition to the features expected from previous structural and spectroscopic studies, two new motifs were observed that may prove important in the design of antibiotics modified to overcome bacterial resistance. A changed binding mode was found in two dipeptide complexes, and a new type of face-to-face oligomerization (in addition to the well-established back-to-back dimerization) was seen when the model peptide reaches a critical fraction of the size of the cell-wall precursor pentapeptide. The extensive interactions involving both antibiotic and peptide molecules in this interface should appreciably enhance the kinetic and thermodynamic stability of the complexes. In the pentapeptide complex, the relative positions of the peptides are close to those required for d-Ala elimination, so this structure may provide a realistic model for the prevention of the enzyme-catalyzed cell-wall crosslinking by antibiotic binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 12054818 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12054818}}
==About this Structure==
==About this Structure==
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[[Category: Glycopeptide]]
[[Category: Glycopeptide]]
[[Category: Vacomycin]]
[[Category: Vacomycin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:51:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:12:11 2008''

Revision as of 05:12, 1 July 2008

Image:1hhu.png

Template:STRUCTURE 1hhu

BALHIMYCIN IN COMPLEX WITH D-ALA-D-ALA

Template:ABSTRACT PUBMED 12054818

About this Structure

Full crystallographic information is available from OCA.

Reference

Structures of glycopeptide antibiotics with peptides that model bacterial cell-wall precursors., Lehmann C, Bunkoczi G, Vertesy L, Sheldrick GM, J Mol Biol. 2002 May 3;318(3):723-32. PMID:12054818

Page seeded by OCA on Tue Jul 1 08:12:11 2008

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