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1hhv

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[[Image:1hhv.gif|left|200px]]
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{{STRUCTURE_1hhv| PDB=1hhv | SCENE= }}
{{STRUCTURE_1hhv| PDB=1hhv | SCENE= }}
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'''SOLUTION STRUCTURE OF VIRUS CHEMOKINE VMIP-II'''
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===SOLUTION STRUCTURE OF VIRUS CHEMOKINE VMIP-II===
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==Overview==
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Human herpesvirus-8 (HHV-8) is the infectious agent responsible for Kaposi's sarcoma and encodes a protein, macrophage inflammatory protein-II (vMIP-II), which shows sequence similarity to the human CC chemokines. vMIP-II has broad receptor specificity that crosses chemokine receptor subfamilies, and inhibits HIV-1 viral entry mediated by numerous chemokine receptors. In this study, the solution structure of chemically synthesized vMIP-II was determined by nuclear magnetic resonance. The protein is a monomer and possesses the chemokine fold consisting of a flexible N-terminus, three antiparallel beta strands, and a C-terminal alpha helix. Except for the N-terminal residues (residues 1-13) and the last two C-terminal residues (residues 73-74), the structure of vMIP-II is well-defined, exhibiting average rmsd of 0.35 and 0.90 A for the backbone heavy atoms and all heavy atoms of residues 14-72, respectively. Taking into account the sequence differences between the various CC chemokines and comparing their three-dimensional structures allows us to implicate residues that influence the quaternary structure and receptor binding and activation of these proteins in solution. The analysis of the sequence and three-dimensional structure of vMIP-II indicates the presence of epitopes involved in binding two receptors CCR2 and CCR5. We propose that vMIP-II was initially specific for CCR5 and acquired receptor-binding properties to CCR2 and other chemokine receptors.
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The line below this paragraph, {{ABSTRACT_PUBMED_11358512}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11358512 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11358512}}
==About this Structure==
==About this Structure==
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1HHV is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HHV OCA].
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1HHV is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HHV OCA].
==Reference==
==Reference==
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[[Category: Virus chemokine]]
[[Category: Virus chemokine]]
[[Category: Vmip-ii]]
[[Category: Vmip-ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:51:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:12:16 2008''

Revision as of 05:12, 1 July 2008

Image:1hhv.png

Template:STRUCTURE 1hhv

SOLUTION STRUCTURE OF VIRUS CHEMOKINE VMIP-II

Template:ABSTRACT PUBMED 11358512

About this Structure

1HHV is a Single protein structure. Full experimental information is available from OCA.

Reference

CCR2 and CCR5 receptor-binding properties of herpesvirus-8 vMIP-II based on sequence analysis and its solution structure., Shao W, Fernandez E, Sachpatzidis A, Wilken J, Thompson DA, Schweitzer BI, Lolis E, Eur J Biochem. 2001 May;268(10):2948-59. PMID:11358512

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