1hi7

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[[Image:1hi7.gif|left|200px]]
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{{STRUCTURE_1hi7| PDB=1hi7 | SCENE= }}
{{STRUCTURE_1hi7| PDB=1hi7 | SCENE= }}
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'''NMR SOLUTION STRUCTURE OF THE DISULPHIDE-LINKED HOMODIMER OF HUMAN TFF1, 10 STRUCTURES'''
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===NMR SOLUTION STRUCTURE OF THE DISULPHIDE-LINKED HOMODIMER OF HUMAN TFF1, 10 STRUCTURES===
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==Overview==
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The trefoil factor family protein, TFF1, forms a homodimer, via a disulphide linkage, that has greater activity in wound healing assays than the monomer. Having previously determined a high-resolution solution structure of a monomeric analogue of TFF1, we now investigate the structure of the homodimer formed by the native sequence. The two putative receptor/ligand recognition domains are found to be well separated, at opposite ends of a flexible linker. This contrasts sharply with the known fixed and compact arrangement of the two trefoil domains of the closely related TFF2, and has significant implications for the mechanism of action and functional specificity of the TFF of proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_11286998}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11286998 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11286998}}
==About this Structure==
==About this Structure==
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1HI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HI7 OCA].
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1HI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HI7 OCA].
==Reference==
==Reference==
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[[Category: Trefoil domain]]
[[Category: Trefoil domain]]
[[Category: Tumor suppressor]]
[[Category: Tumor suppressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:52:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:13:11 2008''

Revision as of 05:13, 1 July 2008

Image:1hi7.png

Template:STRUCTURE 1hi7

NMR SOLUTION STRUCTURE OF THE DISULPHIDE-LINKED HOMODIMER OF HUMAN TFF1, 10 STRUCTURES

Template:ABSTRACT PUBMED 11286998

About this Structure

1HI7 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The solution structure of the disulphide-linked homodimer of the human trefoil protein TFF1., Williams MA, Westley BR, May FE, Feeney J, FEBS Lett. 2001 Mar 30;493(2-3):70-4. PMID:11286998

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