1hiq

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[[Image:1hiq.gif|left|200px]]
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{{Seed}}
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[[Image:1hiq.png|left|200px]]
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{{STRUCTURE_1hiq| PDB=1hiq | SCENE= }}
{{STRUCTURE_1hiq| PDB=1hiq | SCENE= }}
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'''PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS'''
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===PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS===
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==Overview==
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The solution structure of a diabetes-associated mutant human insulin (insulin Los Angeles; PheB24--&gt;Ser) was determined by 13C-edited NMR spectroscopy and distance-geometry/simulated annealing calculations. Among vertebrate insulins PheB24 is invariant, and in crystal structures the aromatic ring appears to anchor the putative receptor-binding surface through long-range packing interactions in the hydrophobic core. B24 substitutions are of particular interest in relation to the mechanism of receptor binding. In one analogue ([GlyB24]insulin), partial unfolding of the B chain has been observed with paradoxical retention of near-native bioactivity. The present study of [SerB24]insulin extends this observation: relative to [GlyB24]insulin, near-native structure is restored despite significant loss of function. To our knowledge, our results provide the first structural study of a diabetes-associated mutant insulin and support the hypothesis that insulin undergoes a change in conformation on receptor binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_8421693}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8421693 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8421693}}
==About this Structure==
==About this Structure==
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1HIQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HIQ OCA].
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1HIQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HIQ OCA].
==Reference==
==Reference==
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[[Category: Weiss, M A.]]
[[Category: Weiss, M A.]]
[[Category: Hormone]]
[[Category: Hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:53:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:14:20 2008''

Revision as of 05:14, 1 July 2008

Image:1hiq.png

Template:STRUCTURE 1hiq

PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS

Template:ABSTRACT PUBMED 8421693

About this Structure

1HIQ is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus., Hua QX, Shoelson SE, Inouye K, Weiss MA, Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):582-6. PMID:8421693

Page seeded by OCA on Tue Jul 1 08:14:20 2008

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