1hiw

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{{STRUCTURE_1hiw| PDB=1hiw | SCENE= }}
{{STRUCTURE_1hiw| PDB=1hiw | SCENE= }}
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'''TRIMERIC HIV-1 MATRIX PROTEIN'''
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===TRIMERIC HIV-1 MATRIX PROTEIN===
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==Overview==
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The human immunodeficiency virus type 1 (HIV-1) matrix protein forms a structural shell associated with the inner viral membrane and performs other essential functions throughout the viral life cycle. The crystal structure of the HIV-1 matrix protein, determined at 2.3 angstrom resolution, reveals that individual matrix molecules are composed of five major helices capped by a three-stranded mixed beta-sheet. Unexpectedly, the protein assembles into a trimer in three different crystal lattices, burying 1880 angstrom2 of accessible surface area at the trimer interfaces. Trimerization appears to create a large, bipartite membrane binding surface in which exposed basic residues could cooperate with the N-terminal myristoyl groups to anchor the protein on the acidic inner membrane of the virus.
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(as it appears on PubMed at http://www.pubmed.gov), where 8610175 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8610175}}
==About this Structure==
==About this Structure==
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[[Category: Matrix protein]]
[[Category: Matrix protein]]
[[Category: P17]]
[[Category: P17]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:14:41 2008''

Revision as of 05:14, 1 July 2008

Image:1hiw.png

Template:STRUCTURE 1hiw

TRIMERIC HIV-1 MATRIX PROTEIN

Template:ABSTRACT PUBMED 8610175

About this Structure

1HIW is a Single protein structure of sequence from Human immunodeficiency virus. Full crystallographic information is available from OCA.

Reference

Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly., Hill CP, Worthylake D, Bancroft DP, Christensen AM, Sundquist WI, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3099-104. PMID:8610175

Page seeded by OCA on Tue Jul 1 08:14:41 2008

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