1g62

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(New page: 200px<br /><applet load="1g62" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g62, resolution 2.5&Aring;" /> '''CRYSTAL STRUCTURE OF ...)
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Revision as of 13:37, 20 November 2007

Image:1g62.gif

1g62, resolution 2.5Å

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CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6

Overview

Ribosome anti-association factor eIF6 (originally named according to, translation initiation terminology as eukaryotic initiation factor 6), binds to the large ribosomal subunit, thereby preventing inappropriate, interactions with the small subunit during initiation of protein, synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five, quasi identical alpha/beta subdomains arrayed about a five-fold axis of, pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association., Comparative protein structure modeling with other known archaeal and, eukaryotic homologs demonstrated the presence of two conserved surface, regions, one or both of which may bind the large ribosomal subunit.

About this Structure

1G62 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:11101899

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