1hjd

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{{STRUCTURE_1hjd| PDB=1hjd | SCENE= }}
{{STRUCTURE_1hjd| PDB=1hjd | SCENE= }}
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'''MELANOMA INHIBITORY ACTIVITY (MIA) PROTEIN'''
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===MELANOMA INHIBITORY ACTIVITY (MIA) PROTEIN===
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==Overview==
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Melanoma inhibitory activity (MIA) protein is a clinically valuable marker in patients with malignant melanoma, as enhanced values diagnose metastatic melanoma stages III and IV. Here we show that the recombinant human MIA adopts an SH3 domain-like fold in solution, with two perpendicular, antiparallel, three- and five-stranded beta-sheets. In contrast to known structures with the SH3 domain fold, MIA is a single-domain protein, and contains an additional antiparallel beta-sheet and two disulfide bonds. MIA is also the first extracellular protein found to have the SH3 domain-like fold. Furthermore, we show that MIA interacts with fibronectin and that the peptide ligands identified for MIA exhibit a matching sequence to type III human fibronectin repeats, especially to FN14, which is close to an integrin alpha4beta1 binding site. The present study, therefore, may explain the role of MIA in metastasis in vivo, and supports a model in which the binding of human MIA to type III repeats of fibronectin competes with integrin binding, thus detaching cells from the extracellular matrix.
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The line below this paragraph, {{ABSTRACT_PUBMED_11157741}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11157741 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11157741}}
==About this Structure==
==About this Structure==
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1HJD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJD OCA].
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1HJD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJD OCA].
==Reference==
==Reference==
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[[Category: Growth factor]]
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[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:54:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:15:56 2008''

Revision as of 05:15, 1 July 2008

Image:1hjd.png

Template:STRUCTURE 1hjd

MELANOMA INHIBITORY ACTIVITY (MIA) PROTEIN

Template:ABSTRACT PUBMED 11157741

About this Structure

1HJD is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold., Stoll R, Renner C, Zweckstetter M, Bruggert M, Ambrosius D, Palme S, Engh RA, Golob M, Breibach I, Buettner R, Voelter W, Holak TA, Bosserhoff AK, EMBO J. 2001 Feb 1;20(3):340-9. PMID:11157741

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