1hmc

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{{STRUCTURE_1hmc| PDB=1hmc | SCENE= }}
{{STRUCTURE_1hmc| PDB=1hmc | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF DIMERIC HUMAN RECOMBINANT MACROPHAGE COLONY STIMULATING FACTOR'''
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===THREE-DIMENSIONAL STRUCTURE OF DIMERIC HUMAN RECOMBINANT MACROPHAGE COLONY STIMULATING FACTOR===
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==Overview==
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Macrophage colony-stimulating factor (M-CSF) triggers the development of cells of the monocyte-macrophage lineage and has a variety of stimulatory effects on mature cells of this class. The biologically active form of M-CSF is a disulfide-linked dimer that activates an intrinsic tyrosine kinase activity on the M-CSF receptor by inducing dimerization of the receptor molecules. The structure of a recombinant human M-CSF dimer, determined at 2.5 angstroms by x-ray crystallography, contains two bundles of four alpha helices laid end-to-end, with an interchain disulfide bond. Individual monomers of M-CSF show a close structural similarity to the cytokines granulocyte-macrophage colony-stimulating factor and human growth hormone. Both of these cytokines are monomeric in their active form, and their specific receptors lack intrinsic tyrosine kinase activity. The similarity of these structures suggests that the receptor binding determinants for all three cytokines may be similar.
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{{ABSTRACT_PUBMED_1455231}}
==About this Structure==
==About this Structure==
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[[Category: Pandit, J.]]
[[Category: Pandit, J.]]
[[Category: Macrophage colony stimulating factor]]
[[Category: Macrophage colony stimulating factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:23:48 2008''

Revision as of 05:23, 1 July 2008

Image:1hmc.png

Template:STRUCTURE 1hmc

THREE-DIMENSIONAL STRUCTURE OF DIMERIC HUMAN RECOMBINANT MACROPHAGE COLONY STIMULATING FACTOR

Template:ABSTRACT PUBMED 1455231

About this Structure

1HMC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor., Pandit J, Bohm A, Jancarik J, Halenbeck R, Koths K, Kim SH, Science. 1992 Nov 20;258(5086):1358-62. PMID:1455231

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