1hmf

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{{STRUCTURE_1hmf| PDB=1hmf | SCENE= }}
{{STRUCTURE_1hmf| PDB=1hmf | SCENE= }}
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'''STRUCTURE OF THE HMG BOX MOTIF IN THE B-DOMAIN OF HMG1'''
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===STRUCTURE OF THE HMG BOX MOTIF IN THE B-DOMAIN OF HMG1===
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==Overview==
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The conserved, abundant chromosomal protein HMG1 consists of two highly homologous, folded, basic DNA-binding domains, each of approximately 80 amino acid residues, and an acidic C-terminal tail. Each folded domain represents an 'HMG box', a sequence motif recently recognized in certain sequence-specific DNA-binding proteins and which also occurs in abundant HMG1-like proteins that bind to DNA without sequence specificity. The HMG box is defined by a set of highly conserved residues (most distinctively aromatic and basic) and appears to define a novel DNA-binding structural motif. We have expressed the HMG box region of the B-domain of rat HMG1 (residues 88-164 of the intact protein) in Escherichia coli and we describe here the determination of its structure by 2D 1H-NMR spectroscopy. There are three alpha-helices (residues 13-29, 34-48 and 50-74), which together account for approximately 75% of the total residues and contain many of the conserved basic and aromatic residues. Strikingly, the molecule is L-shaped, the angle of approximately 80 degrees between the two arms being defined by a cluster of conserved, predominantly aromatic, residues. The distinctive shape of the HMG box motif, which is distinct from hitherto characterized DNA-binding motifs, may be significant in relation to its recognition of four-way DNA junctions.
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{{ABSTRACT_PUBMED_8467791}}
==About this Structure==
==About this Structure==
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1HMF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMF OCA].
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1HMF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMF OCA].
==Reference==
==Reference==
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[[Category: Weir, H M.]]
[[Category: Weir, H M.]]
[[Category: Dna-binding]]
[[Category: Dna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:23:59 2008''

Revision as of 05:24, 1 July 2008

Image:1hmf.png

Template:STRUCTURE 1hmf

STRUCTURE OF THE HMG BOX MOTIF IN THE B-DOMAIN OF HMG1

Template:ABSTRACT PUBMED 8467791

About this Structure

1HMF is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Structure of the HMG box motif in the B-domain of HMG1., Weir HM, Kraulis PJ, Hill CS, Raine AR, Laue ED, Thomas JO, EMBO J. 1993 Apr;12(4):1311-9. PMID:8467791

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