1hmh

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{{Seed}}
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{{STRUCTURE_1hmh| PDB=1hmh | SCENE= }}
{{STRUCTURE_1hmh| PDB=1hmh | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME'''
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===THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME===
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==Overview==
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The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired stems and a core of highly conserved, non-complementary nucleotides essential for catalysis. The X-ray crystallographic structure of a hammerhead RNA-DNA ribozyme-inhibitor complex at 2.6 A resolution reveals that the base-paired stems are A-form helices and that the core has two structural domains. The first domain is formed by the sequence 5'-CUGA following stem I and is a sharp turn identical to the uridine turn of transfer RNA, whereas the second is a non-Watson-Crick three-base-pair duplex with a divalent-ion binding site. The phosphodiester backbone of the DNA inhibitor strand is splayed out at the phosphate 5' to the cleavage site. The structure indicates that the ribozyme may destabilize a substrate strand in order to facilitate twisting of the substrate to allow cleavage of the scissile bond.
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The line below this paragraph, {{ABSTRACT_PUBMED_7969422}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7969422 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7969422}}
==About this Structure==
==About this Structure==
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[[Category: Dna-rna hammerhead ribozyme]]
[[Category: Dna-rna hammerhead ribozyme]]
[[Category: Loop]]
[[Category: Loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:00:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:24:08 2008''

Revision as of 05:24, 1 July 2008

Image:1hmh.png

Template:STRUCTURE 1hmh

THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME

Template:ABSTRACT PUBMED 7969422

About this Structure

Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a hammerhead ribozyme., Pley HW, Flaherty KM, McKay DB, Nature. 1994 Nov 3;372(6501):68-74. PMID:7969422

Page seeded by OCA on Tue Jul 1 08:24:08 2008

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