1hp3

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[[Image:1hp3.jpg|left|200px]]
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{{Seed}}
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[[Image:1hp3.png|left|200px]]
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{{STRUCTURE_1hp3| PDB=1hp3 | SCENE= }}
{{STRUCTURE_1hp3| PDB=1hp3 | SCENE= }}
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'''C-TERMINAL TRUNCATION OF OMEGA-ATRACOTOXIN-HV2A (CT-HV2A)'''
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===C-TERMINAL TRUNCATION OF OMEGA-ATRACOTOXIN-HV2A (CT-HV2A)===
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==Overview==
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We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak structural/functional homology with omega-agatoxin-IVA/B, the prototypic inhibitor of vertebrate P-type calcium channels, suggests that these two toxin families might share a similar mechanism of action despite their vastly different phylogenetic specificities.
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The line below this paragraph, {{ABSTRACT_PUBMED_11522785}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11522785 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11522785}}
==About this Structure==
==About this Structure==
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1HP3 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP3 OCA].
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1HP3 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP3 OCA].
==Reference==
==Reference==
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[[Category: Wang, X H.]]
[[Category: Wang, X H.]]
[[Category: Cystine knot]]
[[Category: Cystine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:05:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:29:24 2008''

Revision as of 05:29, 1 July 2008

Image:1hp3.png

Template:STRUCTURE 1hp3

C-TERMINAL TRUNCATION OF OMEGA-ATRACOTOXIN-HV2A (CT-HV2A)

Template:ABSTRACT PUBMED 11522785

About this Structure

1HP3 is a Single protein structure. Full experimental information is available from OCA.

Reference

Discovery and structure of a potent and highly specific blocker of insect calcium channels., Wang XH, Connor M, Wilson D, Wilson HI, Nicholson GM, Smith R, Shaw D, Mackay JP, Alewood PF, Christie MJ, King GF, J Biol Chem. 2001 Oct 26;276(43):40306-12. Epub 2001 Aug 24. PMID:11522785

Page seeded by OCA on Tue Jul 1 08:29:24 2008

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