1hpt

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[[Image:1hpt.gif|left|200px]]
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{{STRUCTURE_1hpt| PDB=1hpt | SCENE= }}
{{STRUCTURE_1hpt| PDB=1hpt | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF A RECOMBINANT VARIANT OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE)'''
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===THREE-DIMENSIONAL STRUCTURE OF A RECOMBINANT VARIANT OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE)===
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==Overview==
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A modified version of the human pancreatic trypsin inhibitor (PSTI), generated in a protein-design project, has been crystallized in spacegroup P4(3) with lattice constants a = 40.15 A, c = 33.91 A. The structure has been solved by molecular replacement. Refinement of the structure by simulated annealing and conventional restrained least-squares yielded for 8.0 to 2.3 A data a final R-value of 19.1%. Differences to the known structures of porcine PSTI complexed with trypsinogen and modified human PSTI complexed with chymotrypsinogen occur at the flexible N-terminal part of the molecule. These differences are influenced by crystal packing, as are low temperature factors for the binding loop. The geometry of the binding loop is similar to the complexed structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_1613792}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1613792 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1613792}}
==About this Structure==
==About this Structure==
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[[Category: Szardenings, M.]]
[[Category: Szardenings, M.]]
[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:06:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:30:49 2008''

Revision as of 05:30, 1 July 2008

Image:1hpt.png

Template:STRUCTURE 1hpt

THREE-DIMENSIONAL STRUCTURE OF A RECOMBINANT VARIANT OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE)

Template:ABSTRACT PUBMED 1613792

About this Structure

1HPT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type)., Hecht HJ, Szardenings M, Collins J, Schomburg D, J Mol Biol. 1992 Jun 20;225(4):1095-103. PMID:1613792

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