1hqy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1hqy.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1hqy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1hqy| PDB=1hqy | SCENE= }}
{{STRUCTURE_1hqy| PDB=1hqy | SCENE= }}
-
'''Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU'''
+
===Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU===
-
==Overview==
+
<!--
-
BACKGROUND: The bacterial heat shock locus ATPase HslU is an AAA(+) protein that has structures known in many nucleotide-free and -bound states. Nucleotide is required for the formation of the biologically active HslU hexameric assembly. The hexameric HslU ATPase binds the dodecameric HslV peptidase and forms an ATP-dependent HslVU protease. RESULTS: We have characterized four distinct HslU conformational states, going sequentially from open to closed: the empty, SO(4), ATP, and ADP states. The nucleotide binds at a cleft formed by an alpha/beta domain and an alpha-helical domain in HslU. The four HslU states differ by a rotation of the alpha-helical domain. This classification leads to a correction of nucleotide identity in one structure and reveals the ATP hydrolysis-dependent structural changes in the HslVU complex, including a ring rotation and a conformational change of the HslU C terminus. This leads to an amended protein unfolding-coupled translocation mechanism. CONCLUSIONS: The observed nucleotide-dependent conformational changes in HslU and their governing principles provide a framework for the mechanistic understanding of other AAA(+) proteins.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11709174}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11709174 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11709174}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Hslvu]]
[[Category: Hslvu]]
[[Category: Peptidase-atpase complex]]
[[Category: Peptidase-atpase complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:08:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:33:51 2008''

Revision as of 05:33, 1 July 2008

Image:1hqy.png

Template:STRUCTURE 1hqy

Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU

Template:ABSTRACT PUBMED 11709174

About this Structure

1HQY is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU., Wang J, Song JJ, Seong IS, Franklin MC, Kamtekar S, Eom SH, Chung CH, Structure. 2001 Nov;9(11):1107-16. PMID:11709174

Page seeded by OCA on Tue Jul 1 08:33:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hqy"
Personal tools