1hri

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1hri.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1hri.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1hri| PDB=1hri | SCENE= }}
{{STRUCTURE_1hri| PDB=1hri | SCENE= }}
-
'''STRUCTURE DETERMINATION OF ANTIVIRAL COMPOUND SCH 38057 COMPLEXED WITH HUMAN RHINOVIRUS 14'''
+
===STRUCTURE DETERMINATION OF ANTIVIRAL COMPOUND SCH 38057 COMPLEXED WITH HUMAN RHINOVIRUS 14===
-
==Overview==
+
<!--
-
SCH 38057 (1-[6-(2-chloro-4-methoxyphenoxy)-hexyl]imidazole hydrochloride) is a new, water-soluble antiviral compound that has inhibitory activities against a number of picornavirus infections. The structure of the human rhinovirus 14 (HRV14) complex with SCH 38057 was determined at 3.0 A resolution by single-crystal diffraction techniques using synchrotron X-radiation. SCH 38057 was found to bind at the innermost end of the hydrophobic pocket within the capsid protein VP1, a locus of binding of other antipicornaviral agents; however, the complex differs from previously reported complexes in two important aspects. It leaves a considerable volume near the entrance to the binding pocket unoccupied. In addition, the alterations in the conformation of the VP1 polypeptide are similar to, but more extensive than those observed in HRV14 complexes with other antiviral agents. Although only 9 amino acids of VP1 have close contacts with the SCH 38057 molecule (within 3.6 A), at least 36 amino acids from both VP1 and VP3 have significantly altered conformations (C alpha movement &gt; 0.5 A versus native). The structures of complexes of HRV14 with SCH 38057 and WIN 51711 are compared. Aromatic ring interactions between picornavirus capsid residues and antiviral inhibitors are proposed to be among the major determinants for positioning of these compounds.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8386772}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8386772 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8386772}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Coat protein]]
[[Category: Coat protein]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:09:43 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:35:13 2008''

Revision as of 05:35, 1 July 2008

Image:1hri.png

Template:STRUCTURE 1hri

STRUCTURE DETERMINATION OF ANTIVIRAL COMPOUND SCH 38057 COMPLEXED WITH HUMAN RHINOVIRUS 14

Template:ABSTRACT PUBMED 8386772

About this Structure

1HRI is a Protein complex structure of sequences from Human rhinovirus 14. Full crystallographic information is available from OCA.

Reference

Structure determination of antiviral compound SCH 38057 complexed with human rhinovirus 14., Zhang A, Nanni RG, Li T, Arnold GF, Oren DA, Jacobo-Molina A, Williams RL, Kamer G, Rubenstein DA, Li Y, et al., J Mol Biol. 1993 Apr 5;230(3):857-67. PMID:8386772

Page seeded by OCA on Tue Jul 1 08:35:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hri"
Personal tools