1hry

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[[Image:1hry.gif|left|200px]]
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{{Seed}}
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[[Image:1hry.png|left|200px]]
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{{STRUCTURE_1hry| PDB=1hry | SCENE= }}
{{STRUCTURE_1hry| PDB=1hry | SCENE= }}
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'''THE 3D STRUCTURE OF THE HUMAN SRY-DNA COMPLEX SOLVED BY MULTID-DIMENSIONAL HETERONUCLEAR-EDITED AND-FILTERED NMR'''
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===THE 3D STRUCTURE OF THE HUMAN SRY-DNA COMPLEX SOLVED BY MULTID-DIMENSIONAL HETERONUCLEAR-EDITED AND-FILTERED NMR===
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==Overview==
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The solution structure of the specific complex between the high mobility group (HMG) domain of SRY (hSRY-HMG), the protein encoded by the human testis-determining gene, and its DNA target site in the promoter of the mullerian inhibitory substance gene has been determined by multidimensional NMR spectroscopy. hSRY-HMG has a twisted L shape that presents a concave surface (made up of three helices and the N- and C-terminal strands) to the DNA for sequence-specific recognition. Binding of hSRY-HMG to its specific target site occurs exclusively in the minor groove and induces a large conformational change in the DNA. The DNA in the complex has an overall 70 degrees-80 degrees bend and is helically unwound relative to classical A- and B-DNA. The structure of the complex reveals the origin of sequence-specific binding within the HMG-1/HMG-2 family and provides a framework for understanding the effects of point mutations that cause 46X,Y sex reversal at the atomic level.
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The line below this paragraph, {{ABSTRACT_PUBMED_7774012}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7774012 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7774012}}
==About this Structure==
==About this Structure==
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1HRY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRY OCA].
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1HRY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRY OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Sry]]
[[Category: Sry]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:10:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:36:12 2008''

Revision as of 05:36, 1 July 2008

Image:1hry.png

Template:STRUCTURE 1hry

THE 3D STRUCTURE OF THE HUMAN SRY-DNA COMPLEX SOLVED BY MULTID-DIMENSIONAL HETERONUCLEAR-EDITED AND-FILTERED NMR

Template:ABSTRACT PUBMED 7774012

About this Structure

1HRY is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex., Werner MH, Huth JR, Gronenborn AM, Clore GM, Cell. 1995 Jun 2;81(5):705-14. PMID:7774012

Page seeded by OCA on Tue Jul 1 08:36:12 2008

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