1htv

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[[Image:1htv.gif|left|200px]]
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{{Seed}}
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[[Image:1htv.png|left|200px]]
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{{STRUCTURE_1htv| PDB=1htv | SCENE= }}
{{STRUCTURE_1htv| PDB=1htv | SCENE= }}
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'''CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN'''
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===CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN===
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==Overview==
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Destripeptide (B28-B30) insulin (DTRI) is an insulin analogue that has much weaker association ability than native insulin but keeps most of its biological activity. It can be crystallized from a solution containing zinc ions at near-neutral pH. Its crystal structure has been determined by molecular replacement and refined at 1.9 A resolution. DTRI in the crystal exists as a loose hexamer compared with 2Zn insulin. The hexamer only contains one zinc ion that coordinates to the B10 His residues of three monomers. Although residues B28-B30 are located in the monomer-monomer interface within a dimer, the removal of them can simultaneously weaken both the interactions between monomers within the dimer and the interactions between dimers. Because the B-chain C-terminus of insulin is very flexible, we take the DTRI hexamer as a transition state in the native insulin dissociation process and suggest a possible dissociation process of the insulin hexamer based on the DTRI structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_11343787}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11343787 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11343787}}
==About this Structure==
==About this Structure==
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[[Category: Beta sheet]]
[[Category: Beta sheet]]
[[Category: Helix]]
[[Category: Helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:13:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:40:07 2008''

Revision as of 05:40, 1 July 2008

Image:1htv.png

Template:STRUCTURE 1htv

CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN

Template:ABSTRACT PUBMED 11343787

About this Structure

1HTV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of destripeptide (B28-B30) insulin: implications for insulin dissociation., Ye J, Chang W, Liang D, Biochim Biophys Acta. 2001 May 5;1547(1):18-25. PMID:11343787

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