This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1htv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1htv.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1htv.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1htv| PDB=1htv | SCENE= }}
{{STRUCTURE_1htv| PDB=1htv | SCENE= }}
-
'''CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN'''
+
===CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN===
-
==Overview==
+
<!--
-
Destripeptide (B28-B30) insulin (DTRI) is an insulin analogue that has much weaker association ability than native insulin but keeps most of its biological activity. It can be crystallized from a solution containing zinc ions at near-neutral pH. Its crystal structure has been determined by molecular replacement and refined at 1.9 A resolution. DTRI in the crystal exists as a loose hexamer compared with 2Zn insulin. The hexamer only contains one zinc ion that coordinates to the B10 His residues of three monomers. Although residues B28-B30 are located in the monomer-monomer interface within a dimer, the removal of them can simultaneously weaken both the interactions between monomers within the dimer and the interactions between dimers. Because the B-chain C-terminus of insulin is very flexible, we take the DTRI hexamer as a transition state in the native insulin dissociation process and suggest a possible dissociation process of the insulin hexamer based on the DTRI structure.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11343787}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11343787 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11343787}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Beta sheet]]
[[Category: Beta sheet]]
[[Category: Helix]]
[[Category: Helix]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:13:33 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:40:07 2008''

Revision as of 05:40, 1 July 2008

Image:1htv.png

Template:STRUCTURE 1htv

CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN

Template:ABSTRACT PUBMED 11343787

About this Structure

1HTV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of destripeptide (B28-B30) insulin: implications for insulin dissociation., Ye J, Chang W, Liang D, Biochim Biophys Acta. 2001 May 5;1547(1):18-25. PMID:11343787

Page seeded by OCA on Tue Jul 1 08:40:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1htv"
Personal tools