1hu3

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{{STRUCTURE_1hu3| PDB=1hu3 | SCENE= }}
{{STRUCTURE_1hu3| PDB=1hu3 | SCENE= }}
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'''MIDDLE DOMAIN OF HUMAN EIF4GII'''
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===MIDDLE DOMAIN OF HUMAN EIF4GII===
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==Overview==
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The X-ray structure of the phylogenetically conserved middle portion of human eukaryotic initiation factor (eIF) 4GII has been determined at 2.4 A resolution, revealing a crescent-shaped domain consisting of ten alpha helices arranged as five HEAT repeats. Together with the ATP-dependent RNA helicase eIF4A, this HEAT domain suffices for 48S ribosomal complex formation with a picornaviral RNA internal ribosome entry site (IRES). Structure-based site-directed mutagenesis was used to identify two adjacent features on the surface of this essential component of the translation initiation machinery that, respectively, bind eIF4A and a picornaviral IRES. The structural and biochemical results provide mechanistic insights into both cap-dependent and cap-independent translation initiation.
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(as it appears on PubMed at http://www.pubmed.gov), where 11172724 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11172724}}
==About this Structure==
==About this Structure==
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[[Category: Eif4g]]
[[Category: Eif4g]]
[[Category: Heat repeat]]
[[Category: Heat repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:13:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:40:38 2008''

Revision as of 05:40, 1 July 2008

Image:1hu3.png

Template:STRUCTURE 1hu3

MIDDLE DOMAIN OF HUMAN EIF4GII

Template:ABSTRACT PUBMED 11172724

About this Structure

1HU3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery., Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK, Mol Cell. 2001 Jan;7(1):193-203. PMID:11172724

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