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1hv7

From Proteopedia

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[[Image:1hv7.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1hv7| PDB=1hv7 | SCENE= }}
{{STRUCTURE_1hv7| PDB=1hv7 | SCENE= }}
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'''PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A'''
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===PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A===
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==Overview==
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The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.
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The line below this paragraph, {{ABSTRACT_PUBMED_11294386}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11294386 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11294386}}
==About this Structure==
==About this Structure==
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[[Category: Skarzynski, T.]]
[[Category: Skarzynski, T.]]
[[Category: Serine protease-inhibitor complex]]
[[Category: Serine protease-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:15:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:49:21 2008''

Revision as of 05:49, 1 July 2008

Image:1hv7.png

Template:STRUCTURE 1hv7

PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A

Template:ABSTRACT PUBMED 11294386

About this Structure

1HV7 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate., Macdonald SJ, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H, Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8. PMID:11294386

Page seeded by OCA on Tue Jul 1 08:49:21 2008

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