1hvr

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{{STRUCTURE_1hvr| PDB=1hvr | SCENE= }}
{{STRUCTURE_1hvr| PDB=1hvr | SCENE= }}
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'''RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS'''
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===RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS===
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==Overview==
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Mechanistic information and structure-based design methods have been used to design a series of nonpeptide cyclic ureas that are potent inhibitors of human immunodeficiency virus (HIV) protease and HIV replication. A fundamental feature of these inhibitors is the cyclic urea carbonyl oxygen that mimics the hydrogen-bonding features of a key structural water molecule. The success of the design in both displacing and mimicking the structural water molecule was confirmed by x-ray crystallographic studies. Highly selective, preorganized inhibitors with relatively low molecular weight and high oral bioavailability were synthesized.
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(as it appears on PubMed at http://www.pubmed.gov), where 8278812 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8278812}}
==About this Structure==
==About this Structure==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Chang, C H.]]
[[Category: Chang, C H.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:16:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:52:49 2008''

Revision as of 05:52, 1 July 2008

Image:1hvr.png

Template:STRUCTURE 1hvr

RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS

Template:ABSTRACT PUBMED 8278812

About this Structure

1HVR is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors., Lam PY, Jadhav PK, Eyermann CJ, Hodge CN, Ru Y, Bacheler LT, Meek JL, Otto MJ, Rayner MM, Wong YN, et al., Science. 1994 Jan 21;263(5145):380-4. PMID:8278812

Page seeded by OCA on Tue Jul 1 08:52:49 2008

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