1hww

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[[Image:1hww.gif|left|200px]]
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{{Seed}}
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[[Image:1hww.png|left|200px]]
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{{STRUCTURE_1hww| PDB=1hww | SCENE= }}
{{STRUCTURE_1hww| PDB=1hww | SCENE= }}
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'''GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE'''
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===GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE===
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==Overview==
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Golgi alpha-mannosidase II, a key enzyme in N-glycan processing, is a target in the development of anti- cancer therapies. The crystal structure of Drosophila Golgi alpha-mannosidase II in the absence and presence of the anti-cancer agent swainsonine and the inhibitor deoxymannojirimycin reveals a novel protein fold with an active site zinc intricately involved both in the substrate specificity of the enzyme and directly in the catalytic mechanism. Identification of a putative GlcNAc binding pocket in the vicinity of the active site cavity provides a model for the binding of the GlcNAcMan(5)GlcNAc(2) substrate and the consecutive hydrolysis of the alpha1,6- and alpha1,3-linked mannose residues. The enzyme-inhibitor interactions observed provide insight into the catalytic mechanism, opening the door to the design of novel inhibitors of alpha-mannosidase II.
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The line below this paragraph, {{ABSTRACT_PUBMED_11406577}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11406577 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11406577}}
==About this Structure==
==About this Structure==
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[[Category: N-terminal alpha-beta domain]]
[[Category: N-terminal alpha-beta domain]]
[[Category: Three helix bundle]]
[[Category: Three helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:18:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:02:23 2008''

Revision as of 07:02, 1 July 2008

Image:1hww.png

Template:STRUCTURE 1hww

GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE

Template:ABSTRACT PUBMED 11406577

About this Structure

1HWW is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells., van den Elsen JM, Kuntz DA, Rose DR, EMBO J. 2001 Jun 15;20(12):3008-17. PMID:11406577

Page seeded by OCA on Tue Jul 1 10:02:23 2008

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