1hxn

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{{STRUCTURE_1hxn| PDB=1hxn | SCENE= }}
{{STRUCTURE_1hxn| PDB=1hxn | SCENE= }}
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'''1.8 ANGSTROMS CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF RABBIT SERUM HEMOPEXIN'''
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===1.8 ANGSTROMS CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF RABBIT SERUM HEMOPEXIN===
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==Overview==
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BACKGROUND: Haemopexin is a serum glycoprotein that binds haem reversibly and delivers it to the liver where it is taken up by receptor-mediated endocytosis. Haemopexin has two homologous domains, each having a characteristic fourfold internal sequence repeat. Haemopexin-type domains are also found in other proteins, including the serum adhesion protein vitronectin and various collagenases, in which they mediate protein-protein interactions. RESULTS: We have determined the crystal structure of the C-terminal domain of haemopexin at 1.8 A resolution. The domain is folded into four beta-leaflet modules, arranged in succession around a central pseudo-fourfold axis. A funnel-shaped tunnel through the centre of this disc-shaped domain serves as an ion-binding site. CONCLUSIONS: A model for haem binding by haemopexin is proposed, utilizing an anion-binding site at the wider end of the central tunnel, together with an associated cleft. This parallels the active-site location in other beta-propeller structures. The capacity to bind both cations and anions, together with the disc shape of the domain, suggests that such domains may be used widely for macromolecular recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 8590016 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8590016}}
==About this Structure==
==About this Structure==
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[[Category: Faber, H R.]]
[[Category: Faber, H R.]]
[[Category: Heme]]
[[Category: Heme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:05:16 2008''

Revision as of 07:05, 1 July 2008

Image:1hxn.png

Template:STRUCTURE 1hxn

1.8 ANGSTROMS CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF RABBIT SERUM HEMOPEXIN

Template:ABSTRACT PUBMED 8590016

About this Structure

1HXN is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

1.8 A crystal structure of the C-terminal domain of rabbit serum haemopexin., Faber HR, Groom CR, Baker HM, Morgan WT, Smith A, Baker EN, Structure. 1995 Jun 15;3(6):551-9. PMID:8590016

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