1hyj

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{{STRUCTURE_1hyj| PDB=1hyj | SCENE= }}
{{STRUCTURE_1hyj| PDB=1hyj | SCENE= }}
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'''SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN'''
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===SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN===
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==Overview==
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The recruitment of trafficking and signaling proteins to membranes containing phosphatidylinositol 3-phosphate [PtdIns(3)P] is mediated by FYVE domains. Here, the solution structure of the FYVE domain of the early endosome antigen 1 protein (EEA1) in the free state was compared with the structures of the domain complexed with PtdIns(3)P and mixed micelles. The multistep binding mechanism involved nonspecific insertion of a hydrophobic loop into the lipid bilayer, positioning and activating the binding pocket. Ligation of PtdIns(3)P then induced a global structural change, drawing the protein termini over the bound phosphoinositide by extension of a hinge. Specific recognition of the 3-phosphate was determined indirectly and directly by two clusters of conserved arginines.
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(as it appears on PubMed at http://www.pubmed.gov), where 11230696 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11230696}}
==About this Structure==
==About this Structure==
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1HYJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYJ OCA].
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1HYJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYJ OCA].
==Reference==
==Reference==
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[[Category: Beta sheet]]
[[Category: Beta sheet]]
[[Category: Zinc cluster]]
[[Category: Zinc cluster]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:21:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:07:56 2008''

Revision as of 07:07, 1 July 2008

Image:1hyj.png

Template:STRUCTURE 1hyj

SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN

Template:ABSTRACT PUBMED 11230696

About this Structure

1HYJ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural mechanism of endosome docking by the FYVE domain., Kutateladze T, Overduin M, Science. 2001 Mar 2;291(5509):1793-6. PMID:11230696

Page seeded by OCA on Tue Jul 1 10:07:56 2008

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