1hyr

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{{STRUCTURE_1hyr| PDB=1hyr | SCENE= }}
{{STRUCTURE_1hyr| PDB=1hyr | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN MICA IN COMPLEX WITH NATURAL KILLER CELL RECEPTOR NKG2D'''
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===CRYSTAL STRUCTURE OF HUMAN MICA IN COMPLEX WITH NATURAL KILLER CELL RECEPTOR NKG2D===
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==Overview==
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The major histocompatibility complex (MHC) class I homolog, MICA, is a stress-inducible ligand for NKG2D, a C-type lectin-like activating immunoreceptor. The crystal structure of this ligand-receptor complex that we report here reveals an NKG2D homodimer bound to a MICA monomer in an interaction that is analogous to that seen in T cell receptor-MHC class I protein complexes. Similar surfaces on each NKG2D monomer interact with different surfaces on either the alpha1 or alpha2 domains of MICA. The binding interactions are large in area and highly complementary. The central section of the alpha2-domain helix, disordered in the structure of MICA alone, is ordered in the complex and forms part of the NKG2D interface. The extensive flexibility of the interdomain linker of MICA is shown by its altered conformation when crystallized alone or in complex with NKG2D.
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(as it appears on PubMed at http://www.pubmed.gov), where 11323699 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11323699}}
==About this Structure==
==About this Structure==
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[[Category: Mic-a]]
[[Category: Mic-a]]
[[Category: Nkg2d]]
[[Category: Nkg2d]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:22:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:08:29 2008''

Revision as of 07:08, 1 July 2008

Image:1hyr.png

Template:STRUCTURE 1hyr

CRYSTAL STRUCTURE OF HUMAN MICA IN COMPLEX WITH NATURAL KILLER CELL RECEPTOR NKG2D

Template:ABSTRACT PUBMED 11323699

About this Structure

1HYR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA., Li P, Morris DL, Willcox BE, Steinle A, Spies T, Strong RK, Nat Immunol. 2001 May;2(5):443-51. PMID:11323699

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