1hzi

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{{STRUCTURE_1hzi| PDB=1hzi | SCENE= }}
{{STRUCTURE_1hzi| PDB=1hzi | SCENE= }}
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'''INTERLEUKIN-4 MUTANT E9A'''
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===INTERLEUKIN-4 MUTANT E9A===
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==Overview==
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Interleukin 4 (IL-4) is a pleiotropic cytokine which induces T-cell differentiation and class switching of B cells. It therefore plays a central role in the development of allergies and asthma. An IL-4 variant in which Glu9 was mutated to alanine shows an 800-fold drop in binding affinity towards its high-affinity receptor chain. As shown by surface plasmon resonance measurements, this mostly arises from a decreased association rate. Here, the crystal structure of this mutant is reported. It reveals that the protein has a virtually identical structure to the wild type, showing that the unusual behaviour of the mutated protein is not a consequence of misfolding. The possibility that polar interactions in the encounter complex have a steering effect is discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 11526337 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11526337}}
==About this Structure==
==About this Structure==
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[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Il-4]]
[[Category: Il-4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:23:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:10:55 2008''

Revision as of 07:10, 1 July 2008

Image:1hzi.png

Template:STRUCTURE 1hzi

INTERLEUKIN-4 MUTANT E9A

Template:ABSTRACT PUBMED 11526337

About this Structure

1HZI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation., Hulsmeyer M, Scheufler C, Dreyer MK, Acta Crystallogr D Biol Crystallogr. 2001 Sep;57(Pt 9):1334-6. Epub 2001, Aug 23. PMID:11526337

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