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1oa8
From Proteopedia
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(New page: 200px<br /> <applet load="1oa8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oa8, resolution 1.70Å" /> '''AXH DOMAIN OF HUMAN...)
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Revision as of 17:49, 29 October 2007
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AXH DOMAIN OF HUMAN SPINOCEREBELLAR ATAXIN-1
Overview
Spinocerebellar ataxia type 1 is a late-onset neurodegenerative disease, caused by the expansion of a CAG triplet repeat in the SCA1 gene. This, results in the lengthening of a polyglutamine tract in the gene product, ataxin-1. This produces a toxic gain of function that results in specific, neuronal death. A region in ataxin-1, the AXH domain, exhibits significant, sequence similarity to the transcription factor HBP1. This region of the, protein has been implicated in RNA binding and self-association. We have, determined the crystal structure of the AXH domain of ataxin-1. The AXH, domain is dimeric and contains an OB-fold, a structural motif found in, many oligonucleotide-binding proteins, supporting its proposed role in RNA, binding. By structure comparison with other proteins that ... [(full description)]
About this Structure
1OA8 is a [Single protein] structure of sequence from [Homo sapiens] with NA as [ligand]. Full crystallographic information is available from [OCA].
Reference
The structure of the AXH domain of spinocerebellar ataxin-1., Chen YW, Allen MD, Veprintsev DB, Lowe J, Bycroft M, J Biol Chem. 2004 Jan 30;279(5):3758-65. Epub 2003 Oct 28. PMID:14583607
Page seeded by OCA on Mon Oct 29 19:54:34 2007
