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1i1h

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{{STRUCTURE_1i1h| PDB=1i1h | SCENE= }}
{{STRUCTURE_1i1h| PDB=1i1h | SCENE= }}
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'''CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE COMPLEX WITH HYDROGENOBYRINIC ACID'''
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===CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE COMPLEX WITH HYDROGENOBYRINIC ACID===
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==Overview==
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BACKGROUND: The crystal structure of precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12, provides evidence that the mechanism for methyl migration can plausibly be regarded as an allowed [1,5]-sigmatropic shift of a methyl group from C-11 to C-12 at the C ring of precorrin-8x to afford hydrogenobyrinic acid. RESULTS: The dimeric structure of CobH creates a set of shared active sites that readily discriminate between different tautomers of precorrin-8x and select a discrete tautomer for sigmatropic rearrangement. The active site contains a strictly conserved histidine residue close to the site of methyl migration in ring C of the substrate. CONCLUSION: Analysis of the structure with bound product suggests that the [1,5]-sigmatropic shift proceeds by protonation of the ring C nitrogen, leading to subsequent methyl migration.
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The line below this paragraph, {{ABSTRACT_PUBMED_11470433}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11470433 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11470433}}
==About this Structure==
==About this Structure==
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[[Category: Precorrin]]
[[Category: Precorrin]]
[[Category: Vitamin b12]]
[[Category: Vitamin b12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:27:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:16:21 2008''

Revision as of 07:16, 1 July 2008

Image:1i1h.png

Template:STRUCTURE 1i1h

CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE COMPLEX WITH HYDROGENOBYRINIC ACID

Template:ABSTRACT PUBMED 11470433

About this Structure

1I1H is a Single protein structure of sequence from Pseudomonas denitrificans. Full crystallographic information is available from OCA.

Reference

Crystal structure of precorrin-8x methyl mutase., Shipman LW, Li D, Roessner CA, Scott AI, Sacchettini JC, Structure. 2001 Jul 3;9(7):587-96. PMID:11470433

Page seeded by OCA on Tue Jul 1 10:16:21 2008

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