1i1i

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[[Image:1i1i.gif|left|200px]]
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{{Seed}}
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[[Image:1i1i.png|left|200px]]
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{{STRUCTURE_1i1i| PDB=1i1i | SCENE= }}
{{STRUCTURE_1i1i| PDB=1i1i | SCENE= }}
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'''NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE'''
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===NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE===
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==Overview==
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The zinc metallopeptidase neurolysin is shown by x-ray crystallography to have large structural elements erected over the active site region that allow substrate access only through a deep narrow channel. This architecture accounts for specialization of this neuropeptidase to small bioactive peptide substrates without bulky secondary and tertiary structures. In addition, modeling studies indicate that the length of a substrate N-terminal to the site of hydrolysis is restricted to approximately 10 residues by the limited size of the active site cavity. Some structural elements of neurolysin, including a five-stranded beta-sheet and the two active site helices, are conserved with other metallopeptidases. The connecting loop regions of these elements, however, are much extended in neurolysin, and they, together with other open coil elements, line the active site cavity. These potentially flexible elements may account for the ability of the enzyme to cleave a variety of sequences.
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The line below this paragraph, {{ABSTRACT_PUBMED_11248043}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11248043 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11248043}}
==About this Structure==
==About this Structure==
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[[Category: Neuropeptidase]]
[[Category: Neuropeptidase]]
[[Category: Zinc metallopeptidase]]
[[Category: Zinc metallopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:27:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:16:28 2008''

Revision as of 07:16, 1 July 2008

Image:1i1i.png

Template:STRUCTURE 1i1i

NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE

Template:ABSTRACT PUBMED 11248043

About this Structure

1I1I is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of neurolysin reveals a deep channel that limits substrate access., Brown CK, Madauss K, Lian W, Beck MR, Tolbert WD, Rodgers DW, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3127-32. Epub 2001 Mar 6. PMID:11248043

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