1i1q

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[[Image:1i1q.gif|left|200px]]
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{{Seed}}
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[[Image:1i1q.png|left|200px]]
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{{STRUCTURE_1i1q| PDB=1i1q | SCENE= }}
{{STRUCTURE_1i1q| PDB=1i1q | SCENE= }}
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'''STRUCTURE OF THE COOPERATIVE ALLOSTERIC ANTHRANILATE SYNTHASE FROM SALMONELLA TYPHIMURIUM'''
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===STRUCTURE OF THE COOPERATIVE ALLOSTERIC ANTHRANILATE SYNTHASE FROM SALMONELLA TYPHIMURIUM===
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==Overview==
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We have determined the X-ray crystal structure of the cooperative anthranilate synthase heterotetramer from Salmonella typhimurium at 1.9 A resolution with the allosteric inhibitor l-tryptophan bound to a regulatory site in the TrpE subunit. Tryptophan binding orders a loop that in turn stabilizes the inactive T state of the enzyme by restricting closure of the active site cleft. Comparison with the structure of the unliganded, noncooperative anthranilate synthase heterotetramer from Sulfolobus solfataricus shows that the two homologs have completely different quarternary structures, even though their functional dimer pairs are structurally similar, consistent with differences in the cooperative behavior of the enzymes. The structural model rationalizes mutational and biochemical studies of the enzyme and establishes the structural differences between cooperative and noncooperative anthranilate synthase homologs.
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The line below this paragraph, {{ABSTRACT_PUBMED_11224570}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11224570 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11224570}}
==About this Structure==
==About this Structure==
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[[Category: Morollo, A A.]]
[[Category: Morollo, A A.]]
[[Category: Tryptophan biosynthesis]]
[[Category: Tryptophan biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:28:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:17:12 2008''

Revision as of 07:17, 1 July 2008

Image:1i1q.png

Template:STRUCTURE 1i1q

STRUCTURE OF THE COOPERATIVE ALLOSTERIC ANTHRANILATE SYNTHASE FROM SALMONELLA TYPHIMURIUM

Template:ABSTRACT PUBMED 11224570

About this Structure

1I1Q is a Protein complex structure of sequences from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium., Morollo AA, Eck MJ, Nat Struct Biol. 2001 Mar;8(3):243-7. PMID:11224570

Page seeded by OCA on Tue Jul 1 10:17:12 2008

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