1i25

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[[Image:1i25.jpg|left|200px]]
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[[Image:1i25.png|left|200px]]
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{{STRUCTURE_1i25| PDB=1i25 | SCENE= }}
{{STRUCTURE_1i25| PDB=1i25 | SCENE= }}
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'''Three dimensional solution structure of huwentoxin-II by 2D 1H-NMR'''
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===Three dimensional solution structure of huwentoxin-II by 2D 1H-NMR===
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==Overview==
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The three-dimensional structure of huwentoxin-II (HWTX-II), an insecticidal peptide purified from the venom of spider Selenocosmia huwena with a unique disulfide bond linkage as I-III, II-V, and IV-VI, has been determined using 2D (1)H-NMR. The resulting structure of HWTX-II contains two beta-turns (C4-S7 and K24-W27) and a double-stranded antiparallel beta-sheet (W27-C29 and C34-K36). Although the C-terminal double-stranded beta-sheet cross-linked by two disulfide bonds (II-V and IV-VI in HWTX-II, II-V and III-VI in the ICK molecules) is conserved both in HWTX-II and the ICK molecules, the structure of HWTX-II is unexpected absence of the cystine knot because of its unique disulfide linkage. It suggests that HWTX-II adopts a novel scaffold different from the ICK motif that is adopted by all other spider toxin structures elucidated thus far. Furthermore, the structure of HWTX-II, which conforms to the disulfide-directed beta-hairpin (DDH) motif, not only supports the hypothesis that the ICK is a minor elaboration of the more ancestral DDH motif but also suggests that HWTX-II may have evolved from the same structural ancestor.
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(as it appears on PubMed at http://www.pubmed.gov), where 11790834 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11790834}}
==About this Structure==
==About this Structure==
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1I25 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I25 OCA].
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1I25 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I25 OCA].
==Reference==
==Reference==
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[[Category: Insecticidal toxin]]
[[Category: Insecticidal toxin]]
[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:29:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:18:06 2008''

Revision as of 07:18, 1 July 2008

Image:1i25.png

Template:STRUCTURE 1i25

Three dimensional solution structure of huwentoxin-II by 2D 1H-NMR

Template:ABSTRACT PUBMED 11790834

About this Structure

1I25 is a Single protein structure of sequence from Ornithoctonus huwena. Full experimental information is available from OCA.

Reference

The structure of spider toxin huwentoxin-II with unique disulfide linkage: evidence for structural evolution., Shu Q, Lu SY, Gu XC, Liang SP, Protein Sci. 2002 Feb;11(2):245-52. PMID:11790834

Page seeded by OCA on Tue Jul 1 10:18:06 2008

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