1i2m

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[[Image:1i2m.jpg|left|200px]]
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{{STRUCTURE_1i2m| PDB=1i2m | SCENE= }}
{{STRUCTURE_1i2m| PDB=1i2m | SCENE= }}
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'''RAN-RCC1-SO4 COMPLEX'''
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===RAN-RCC1-SO4 COMPLEX===
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==Overview==
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RCC1 (regulator of chromosome condensation), a beta propeller chromatin-bound protein, is the guanine nucleotide exchange factor (GEF) for the nuclear GTP binding protein Ran. We report here the 1.8 A crystal structure of a Ran*RCC1 complex in the absence of nucleotide, an intermediate in the multistep GEF reaction. In contrast to previous structures, the phosphate binding region of the nucleotide binding site is perturbed only marginally, possibly due to the presence of a polyvalent anion in the P loop. Biochemical experiments show that a sulfate ion stabilizes the Ran*RCC1 complex and inhibits dissociation by guanine nucleotides. Based on the available structural and biochemical evidence, we present a unified scenario for the GEF mechanism where interaction of the P loop lysine with an acidic residue is a crucial element for the overall reaction.
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The line below this paragraph, {{ABSTRACT_PUBMED_11336674}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11336674 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11336674}}
==About this Structure==
==About this Structure==
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[[Category: Beta-propeller]]
[[Category: Beta-propeller]]
[[Category: G fold or gtpase fold]]
[[Category: G fold or gtpase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:29:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:19:02 2008''

Revision as of 07:19, 1 July 2008

Image:1i2m.png

Template:STRUCTURE 1i2m

RAN-RCC1-SO4 COMPLEX

Template:ABSTRACT PUBMED 11336674

About this Structure

1I2M is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)., Renault L, Kuhlmann J, Henkel A, Wittinghofer A, Cell. 2001 Apr 20;105(2):245-55. PMID:11336674

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