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1i3o

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[[Image:1i3o.gif|left|200px]]
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{{Seed}}
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[[Image:1i3o.png|left|200px]]
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{{STRUCTURE_1i3o| PDB=1i3o | SCENE= }}
{{STRUCTURE_1i3o| PDB=1i3o | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3'''
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===CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3===
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==Overview==
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The molecular mechanism(s) that regulate apoptosis by caspase inhibition remain poorly understood. The main endogenous inhibitors are members of the IAP family and are exemplified by XIAP, which regulates the initiator caspase-9, and the executioner caspases-3 and -7. We report the crystal structure of the second BIR domain of XIAP (BIR2) in complex with caspase-3, at a resolution of 2.7 A, revealing the structural basis for inhibition. The inhibitor makes limited contacts through its BIR domain to the surface of the enzyme, and most contacts to caspase-3 originate from the N-terminal extension. This lies across the substrate binding cleft, but in reverse orientation compared to substrate binding. The mechanism of inhibition is due to a steric blockade prohibitive of substrate binding, and is distinct from the mechanism utilized by synthetic substrate analog inhibitors.
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The line below this paragraph, {{ABSTRACT_PUBMED_11257232}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11257232 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11257232}}
==About this Structure==
==About this Structure==
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[[Category: Complex]]
[[Category: Complex]]
[[Category: Iap]]
[[Category: Iap]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:32:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:22:01 2008''

Revision as of 07:22, 1 July 2008

Image:1i3o.png

Template:STRUCTURE 1i3o

CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3

Template:ABSTRACT PUBMED 11257232

About this Structure

1I3O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the inhibition of caspase-3 by XIAP., Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS, Cell. 2001 Mar 9;104(5):791-800. PMID:11257232

Page seeded by OCA on Tue Jul 1 10:22:01 2008

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