1i3r

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{{STRUCTURE_1i3r| PDB=1i3r | SCENE= }}
{{STRUCTURE_1i3r| PDB=1i3r | SCENE= }}
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'''CRYSTAL STRUCTURE OF A MUTANT IEK CLASS II MHC MOLECULE'''
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===CRYSTAL STRUCTURE OF A MUTANT IEK CLASS II MHC MOLECULE===
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==Overview==
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IE/DR MHC class II molecules have an extensive H-bonding network under the bound peptide. In IE(k), two alpha chain acidic amino acids in the core of this network were mutated to amides. At low pH, the mutant molecule exchanged peptide much more rapidly than the wild-type. The crystal structure of the mutant IE(k) revealed the loss of a single buried water molecule and a reorganization of the predicted H-bonding network. We suggest that these mutations enhance the transition of MHC class II to an open conformation at low pH allowing the bound peptide to escape. In wild-type IE(k), the need to protonate these amino acids also may be a bottleneck in the return to a closed conformation after peptide binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 11371354 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11371354}}
==About this Structure==
==About this Structure==
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[[Category: Mhc classii]]
[[Category: Mhc classii]]
[[Category: Peptide]]
[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:32:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:22:20 2008''

Revision as of 07:22, 1 July 2008

Image:1i3r.png

Template:STRUCTURE 1i3r

CRYSTAL STRUCTURE OF A MUTANT IEK CLASS II MHC MOLECULE

Template:ABSTRACT PUBMED 11371354

About this Structure

1I3R is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Mutations changing the kinetics of class II MHC peptide exchange., Wilson N, Fremont D, Marrack P, Kappler J, Immunity. 2001 May;14(5):513-22. PMID:11371354

Page seeded by OCA on Tue Jul 1 10:22:20 2008

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