1i3z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1i3z.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1i3z.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1i3z| PDB=1i3z | SCENE= }}
{{STRUCTURE_1i3z| PDB=1i3z | SCENE= }}
-
'''MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE'''
+
===MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE===
-
==Overview==
+
<!--
-
The T and natural killer (NK) cell-specific gene SAP (SH2D1A) encodes a 'free SH2 domain' that binds a specific tyrosine motif in the cytoplasmic tail of SLAM (CD150) and related cell surface proteins. Mutations in SH2D1A cause the X-linked lymphoproliferative disease, a primary immunodeficiency. Here we report that a second gene encoding a free SH2 domain, EAT-2, is expressed in macrophages and B lympho cytes. The EAT-2 structure in complex with a phosphotyrosine peptide containing a sequence motif with Tyr281 of the cytoplasmic tail of CD150 is very similar to the structure of SH2D1A complexed with the same peptide. This explains the high affinity of EAT-2 for the pTyr motif in the cytoplasmic tail of CD150 but, unlike SH2D1A, EAT-2 does not bind to non-phosphorylated CD150. EAT-2 binds to the phosphorylated receptors CD84, CD150, CD229 and CD244, and acts as a natural inhibitor, which interferes with the recruitment of the tyrosine phosphatase SHP-2. We conclude that EAT-2 plays a role in controlling signal transduction through at least four receptors expressed on the surface of professional antigen-presenting cells.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11689425}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11689425 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11689425}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Terhorst, C.]]
[[Category: Terhorst, C.]]
[[Category: Sh2 domain phosphotyrosine signal transduction lymphocyte]]
[[Category: Sh2 domain phosphotyrosine signal transduction lymphocyte]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:32:46 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:22:51 2008''

Revision as of 07:22, 1 July 2008

Image:1i3z.png

Template:STRUCTURE 1i3z

MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE

Template:ABSTRACT PUBMED 11689425

About this Structure

1I3Z is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells., Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C, EMBO J. 2001 Nov 1;20(21):5840-52. PMID:11689425

Page seeded by OCA on Tue Jul 1 10:22:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i3z"
Personal tools