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1i4f

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[[Image:1i4f.gif|left|200px]]
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{{STRUCTURE_1i4f| PDB=1i4f | SCENE= }}
{{STRUCTURE_1i4f| PDB=1i4f | SCENE= }}
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'''CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX'''
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===CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX===
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==Overview==
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The heterotrimeric complex of the human major histocompatibity complex (MHC) molecule HLA-A*0201, beta2-microglobulin and the decameric peptide GVYDGREHTV derived from the melanoma antigen (MAGE-A4 protein has been determined by X-ray crystallography at 1.4 A resolution. MAGE-A4 belongs to a family of genes that are specifically expressed in a variety of tumours. MAGE-A4-derived peptides are presented by MHC molecules at the cell surface to cytotoxic T-lymphocytes. As the HLA-A*0201:MAGE-A4 complex occurs only on tumour cells, it is considered to be an appropriate target for immunotherapy. The structure presented here reveals potential epitopes specific to the complex and indicates which peptide residues could be recognised by T-cell receptors. In addition, as the structure could be refined anisotropically, it was possible to describe the movements of the bound peptide in more detail.
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(as it appears on PubMed at http://www.pubmed.gov), where 11502003 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11502003}}
==Disease==
==Disease==
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[[Category: Major histocompatibility complex]]
[[Category: Major histocompatibility complex]]
[[Category: Melanoma-associated antigen]]
[[Category: Melanoma-associated antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:33:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:24:06 2008''

Revision as of 07:24, 1 July 2008

Image:1i4f.png

Template:STRUCTURE 1i4f

Contents

CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX

Template:ABSTRACT PUBMED 11502003

Disease

Known disease associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Stevens-Johnson syndrome, susceptibility to OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1I4F is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene., Hillig RC, Coulie PG, Stroobant V, Saenger W, Ziegler A, Hulsmeyer M, J Mol Biol. 2001 Jul 27;310(5):1167-76. PMID:11502003

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