1i4o

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[[Image:1i4o.gif|left|200px]]
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{{Seed}}
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[[Image:1i4o.png|left|200px]]
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{{STRUCTURE_1i4o| PDB=1i4o | SCENE= }}
{{STRUCTURE_1i4o| PDB=1i4o | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE XIAP/CASPASE-7 COMPLEX'''
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===CRYSTAL STRUCTURE OF THE XIAP/CASPASE-7 COMPLEX===
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==Overview==
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The inhibitor of apoptosis proteins (IAPs) represent the only endogenous caspase inhibitors and are characterized by the presence of baculoviral IAP repeats (BIRs). Here, we report the crystal structure of the complex between human caspase-7 and XIAP (BIR2 and the proceeding linker). The structure surprisingly reveals that the linker is the only contacting element for the caspase, while the BIR2 domain is invisible in the crystal. The linker interacts with and blocks the substrate groove of the caspase in a backward fashion, distinct from substrate recognition. Structural analyses suggest that the linker is the energetic and specificity determinant of the interaction. Further biochemical characterizations clearly establish that the linker harbors the major energetic determinant, while the BIR2 domain serves as a regulatory element for caspase binding and Smac neutralization.
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(as it appears on PubMed at http://www.pubmed.gov), where 11257231 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11257231}}
==About this Structure==
==About this Structure==
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[[Category: Wu, H.]]
[[Category: Wu, H.]]
[[Category: Protease-inhibitor]]
[[Category: Protease-inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:34:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:24:47 2008''

Revision as of 07:24, 1 July 2008

Image:1i4o.png

Template:STRUCTURE 1i4o

CRYSTAL STRUCTURE OF THE XIAP/CASPASE-7 COMPLEX

Template:ABSTRACT PUBMED 11257231

About this Structure

1I4O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain., Huang Y, Park YC, Rich RL, Segal D, Myszka DG, Wu H, Cell. 2001 Mar 9;104(5):781-90. PMID:11257231

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