1i5n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1i5n.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1i5n.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1i5n| PDB=1i5n | SCENE= }}
{{STRUCTURE_1i5n| PDB=1i5n | SCENE= }}
-
'''Crystal structure of the P1 domain of CheA from Salmonella typhimurium'''
+
===Crystal structure of the P1 domain of CheA from Salmonella typhimurium===
-
==Overview==
+
<!--
-
The x-ray crystal structure of the P1 or H domain of the Salmonella CheA protein has been solved at 2.1-A resolution. The structure is composed of an up-down up-down four-helix bundle that is typical of histidine phosphotransfer or HPt domains such as Escherichia coli ArcB(C) and Saccharomyces cerevisiae Ypd1. Loop regions and additional structural features distinguish all three proteins. The CheA domain has an additional C-terminal helix that lies over the surface formed by the C and D helices. The phosphoaccepting His-48 is located at a solvent-exposed position in the middle of the B helix where it is surrounded by several residues that are characteristic of other HPt domains. Mutagenesis studies indicate that conserved glutamate and lysine residues that are part of a hydrogen-bond network with His-48 are essential for the ATP-dependent phosphorylation reaction but not for the phosphotransfer reaction with CheY. These results suggest that the CheA-P1 domain may serve as a good model for understanding the general function of HPt domains in complex two-component phosphorelay systems.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11387324}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11387324 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11387324}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Tolstyk, T.]]
[[Category: Tolstyk, T.]]
[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:36:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:27:34 2008''

Revision as of 07:27, 1 July 2008

Image:1i5n.png

Template:STRUCTURE 1i5n

Crystal structure of the P1 domain of CheA from Salmonella typhimurium

Template:ABSTRACT PUBMED 11387324

About this Structure

1I5N is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Crystal structure of the CheA histidine phosphotransfer domain that mediates response regulator phosphorylation in bacterial chemotaxis., Mourey L, Da Re S, Pedelacq JD, Tolstykh T, Faurie C, Guillet V, Stock JB, Samama JP, J Biol Chem. 2001 Aug 17;276(33):31074-82. Epub 2001 May 31. PMID:11387324

Page seeded by OCA on Tue Jul 1 10:27:34 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i5n"
Personal tools