1i5t

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[[Image:1i5t.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1i5t| PDB=1i5t | SCENE= }}
{{STRUCTURE_1i5t| PDB=1i5t | SCENE= }}
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'''SOLUTION STRUCTURE OF CYANOFERRICYTOCHROME C'''
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===SOLUTION STRUCTURE OF CYANOFERRICYTOCHROME C===
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==Overview==
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The solution structure of cyanoferricytochrome c has been determined using NMR spectroscopy. As a result of including additional constraints derived from pseudocontact shifts, a high-resolution NMR structure was obtained with high accuracy. In order to study the conformational transition between the native protein and its ligand adducts, the present structure was compared with the solution structures of the wild-type cytochrome c and the imidazole-cytochrome c complex. Like the solution structure of imidazole-cytochrome c, the heme crevice is widened by the swinging out of residues 77-85 and a noticeable shift of the 50s helix. However, unlike imidazole, cyanide exerts less significant perturbation on the conformation of the heme cavity, which is revealed by a more compact residue package in the distal pocket. Furthermore, comparison of the solution structure of CN-iso-1Met80Ala cytochrome c with the structure of cyanoferricytochrome c indicated that the binding of cyanide has a different impact on the distal cavity conformation in the two proteins. In addition, the magnetic properties of the present system are discussed and a comprehensive study of the electronic structure of ligand-cytochrome c complexes and the native protein is also described. Electronic supplementary material to this paper can be obtained by using the Springer Link server located at http://dx.doi.org/10.1007/s00775-001-0334-y.
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(as it appears on PubMed at http://www.pubmed.gov), where 11941512 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11941512}}
==About this Structure==
==About this Structure==
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1I5T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5T OCA].
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1I5T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5T OCA].
==Reference==
==Reference==
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[[Category: Cytochrome c]]
[[Category: Cytochrome c]]
[[Category: Nmr structure]]
[[Category: Nmr structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:27:55 2008''

Revision as of 07:27, 1 July 2008

Image:1i5t.png

Template:STRUCTURE 1i5t

SOLUTION STRUCTURE OF CYANOFERRICYTOCHROME C

Template:ABSTRACT PUBMED 11941512

About this Structure

1I5T is a Single protein structure of sequence from Equus caballus. Full experimental information is available from OCA.

Reference

Solution structure of cyanoferricytochrome c: ligand-controlled conformational flexibility and electronic structure of the heme moiety., Yao Y, Qian C, Ye K, Wang J, Bai Z, Tang W, J Biol Inorg Chem. 2002 Apr;7(4-5):539-47. Epub 2002 Jan 31. PMID:11941512

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