We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1i6v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1i6v.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1i6v.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1i6v| PDB=1i6v | SCENE= }}
{{STRUCTURE_1i6v| PDB=1i6v | SCENE= }}
-
'''THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX'''
+
===THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX===
-
==Overview==
+
<!--
-
Rifampicin (Rif) is one of the most potent and broad spectrum antibiotics against bacterial pathogens and is a key component of anti-tuberculosis therapy, stemming from its inhibition of the bacterial RNA polymerase (RNAP). We determined the crystal structure of Thermus aquaticus core RNAP complexed with Rif. The inhibitor binds in a pocket of the RNAP beta subunit deep within the DNA/RNA channel, but more than 12 A away from the active site. The structure, combined with biochemical results, explains the effects of Rif on RNAP function and indicates that the inhibitor acts by directly blocking the path of the elongating RNA when the transcript becomes 2 to 3 nt in length.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11290327}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11290327 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11290327}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:38:35 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:30:20 2008''

Revision as of 07:30, 1 July 2008

Image:1i6v.png

Template:STRUCTURE 1i6v

THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX

Template:ABSTRACT PUBMED 11290327

About this Structure

1I6V is a Protein complex structure of sequences from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Structural mechanism for rifampicin inhibition of bacterial rna polymerase., Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA, Cell. 2001 Mar 23;104(6):901-12. PMID:11290327

Page seeded by OCA on Tue Jul 1 10:30:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i6v"
Personal tools