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1i7w

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[[Image:1i7w.gif|left|200px]]
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{{Seed}}
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[[Image:1i7w.png|left|200px]]
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{{STRUCTURE_1i7w| PDB=1i7w | SCENE= }}
{{STRUCTURE_1i7w| PDB=1i7w | SCENE= }}
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'''BETA-CATENIN/PHOSPHORYLATED E-CADHERIN COMPLEX'''
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===BETA-CATENIN/PHOSPHORYLATED E-CADHERIN COMPLEX===
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==Overview==
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As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly.
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The line below this paragraph, {{ABSTRACT_PUBMED_11348595}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11348595 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11348595}}
==About this Structure==
==About this Structure==
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[[Category: Phosphoserine]]
[[Category: Phosphoserine]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:41:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:33:19 2008''

Revision as of 07:33, 1 July 2008

Image:1i7w.png

Template:STRUCTURE 1i7w

BETA-CATENIN/PHOSPHORYLATED E-CADHERIN COMPLEX

Template:ABSTRACT PUBMED 11348595

About this Structure

1I7W is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin., Huber AH, Weis WI, Cell. 2001 May 4;105(3):391-402. PMID:11348595

Page seeded by OCA on Tue Jul 1 10:33:19 2008

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