1i7z

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[[Image:1i7z.jpg|left|200px]]
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{{Seed}}
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[[Image:1i7z.png|left|200px]]
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{{STRUCTURE_1i7z| PDB=1i7z | SCENE= }}
{{STRUCTURE_1i7z| PDB=1i7z | SCENE= }}
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'''ANTIBODY GNC92H2 BOUND TO LIGAND'''
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===ANTIBODY GNC92H2 BOUND TO LIGAND===
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==Overview==
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Murine monoclonal antibody GNC92H2 was elicited by active immunization with a cocaine immunoconjugate and binds free cocaine with excellent specificity and moderate affinity. Improvement of affinity, as well as humanization of GNC92H2, would be advantageous in immunopharmacotherapy for cocaine addiction, and for emergency cases of drug overdose. Toward this end, the crystal structure of an engineered murine-human chimeric Fab of GNC92H2 complexed with cocaine was determined at 2.3 A resolution. Structural analysis reveals a binding pocket with high shape and charge complementarity to the cocaine framework, which explains the specificity for cocaine, as opposed to the pharmacologically inactive cocaine metabolites. Importantly, the structure provides a foundation for mutagenesis to enhance the binding affinity for cocaine and potent cocaine derivatives, such as cocaethylene, and for additional humanization of the antibody.
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(as it appears on PubMed at http://www.pubmed.gov), where 11469854 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11469854}}
==About this Structure==
==About this Structure==
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[[Category: Chimera]]
[[Category: Chimera]]
[[Category: Igg fold]]
[[Category: Igg fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:41:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:33:39 2008''

Revision as of 07:33, 1 July 2008

Image:1i7z.png

Template:STRUCTURE 1i7z

ANTIBODY GNC92H2 BOUND TO LIGAND

Template:ABSTRACT PUBMED 11469854

About this Structure

1I7Z is a Protein complex structure of sequences from Mus musculus and homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a cocaine-binding antibody., Larsen NA, Zhou B, Heine A, Wirsching P, Janda KD, Wilson IA, J Mol Biol. 2001 Aug 3;311(1):9-15. PMID:11469854

Page seeded by OCA on Tue Jul 1 10:33:39 2008

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