1i8k

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[[Image:1i8k.gif|left|200px]]
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{{STRUCTURE_1i8k| PDB=1i8k | SCENE= }}
{{STRUCTURE_1i8k| PDB=1i8k | SCENE= }}
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'''CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT LIQUID NITROGEN TEMPERATURE'''
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===CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT LIQUID NITROGEN TEMPERATURE===
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==Overview==
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Epitope mapping studies and the determination of the structure to 1.8 A resolution have been carried out for the antigen-binding fragment MR1 in complex with peptide antigen. MR1 is specific for the novel fusion junction of the mutant epidermal growth factor receptor EGFRvIII and has been reported to have a high degree of specificity for the mutant EGFRvIII over the wild-type EGF receptor. The structure of the complex shows that the peptide antigen residue side-chains found by epitope mapping studies to be critical for recognition are accommodated in pockets on the surface of the Fv. However, the most distinctive portion of the peptide antigen, the novel fusion glycine residue, makes no contact to the Fv and does not contribute directly to the epitope. The specificity of MR1 lies in the ability of this glycine residue to assume the restricted conformation needed to form a type II' beta-hairpin turn more easily, and demonstrates that a peptide antigen can be used to generate a conformational epitope.
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(as it appears on PubMed at http://www.pubmed.gov), where 11352579 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11352579}}
==About this Structure==
==About this Structure==
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[[Category: Peptide antigen]]
[[Category: Peptide antigen]]
[[Category: Type ii' beta turn.]]
[[Category: Type ii' beta turn.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:35:05 2008''

Revision as of 07:35, 1 July 2008

Image:1i8k.png

Template:STRUCTURE 1i8k

CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT LIQUID NITROGEN TEMPERATURE

Template:ABSTRACT PUBMED 11352579

About this Structure

1I8K is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Antibody recognition of a conformational epitope in a peptide antigen: Fv-peptide complex of an antibody fragment specific for the mutant EGF receptor, EGFRvIII., Landry RC, Klimowicz AC, Lavictoire SJ, Borisova S, Kottachchi DT, Lorimer IA, Evans SV, J Mol Biol. 2001 May 18;308(5):883-93. PMID:11352579

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