1i9f

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{{Seed}}
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{{STRUCTURE_1i9f| PDB=1i9f | SCENE= }}
{{STRUCTURE_1i9f| PDB=1i9f | SCENE= }}
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'''STRUCTURAL CHARACTERIZATION OF THE COMPLEX OF THE REV RESPONSE ELEMENT RNA WITH A SELECTED PEPTIDE'''
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===STRUCTURAL CHARACTERIZATION OF THE COMPLEX OF THE REV RESPONSE ELEMENT RNA WITH A SELECTED PEPTIDE===
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==Overview==
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INTRODUCTION: The RSG-1.2 peptide was selected for specific binding to the Rev response element RNA, as the natural Rev peptide does. The RSG-1.2 sequence has features incompatible with the helical structure of the bound Rev peptide, indicating that it must bind in a different conformation. RESULTS: The binding of the RSG-1.2 peptide to the Rev response element RNA was characterized using multinuclear, multidimensional NMR. The RSG-1.2 peptide is shown to bind with the N-terminal segment of the peptide along the major groove in an extended conformation and turn preceding a C-terminal helical segment, which crosses the RNA groove in the region widened by the presence of purine-purine base pairs. These features make the details of the bound state rather different than that of the Rev peptide which targets the same RNA sequence binding as a single helix along the groove axis. CONCLUSIONS: These studies further demonstrate the versatility of arginine-rich peptides in recognition of specific RNA elements and the lack of conserved structural features in the bound state.
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The line below this paragraph, {{ABSTRACT_PUBMED_11358697}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11358697 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11358697}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9F OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9F OCA].
==Reference==
==Reference==
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[[Category: Selected peptide]]
[[Category: Selected peptide]]
[[Category: Solution structure]]
[[Category: Solution structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:44:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:37:30 2008''

Revision as of 07:37, 1 July 2008

Image:1i9f.png

Template:STRUCTURE 1i9f

STRUCTURAL CHARACTERIZATION OF THE COMPLEX OF THE REV RESPONSE ELEMENT RNA WITH A SELECTED PEPTIDE

Template:ABSTRACT PUBMED 11358697

About this Structure

Full experimental information is available from OCA.

Reference

Structural characterization of the complex of the Rev response element RNA with a selected peptide., Zhang Q, Harada K, Cho HS, Frankel AD, Wemmer DE, Chem Biol. 2001 May;8(5):511-20. PMID:11358697

Page seeded by OCA on Tue Jul 1 10:37:30 2008

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