1i9k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1i9k.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1i9k.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1i9k| PDB=1i9k | SCENE= }}
{{STRUCTURE_1i9k| PDB=1i9k | SCENE= }}
-
'''THE RNA I-MOTIF'''
+
===THE RNA I-MOTIF===
-
==Overview==
+
<!--
-
Oligodeoxynucleotides with stretches of cytidine residues associate into a four-stranded structure, the i-motif, in which two head-to-tail, intercalated, parallel-stranded duplexes are held together by hemiprotonated C.C+ pairs. We have investigated the possibility of forming an i-motif structure with C-rich ribonucleic acids. The four C-rich RNAs studied, r(UC5), r(C5), r(C5U) and r(UC3), associate into multiple intercalated structures at acidic pH. r(UC5) forms two i-motif structures that differ by their intercalation topologies. We report on a structural study of the main form and we analyze the small conformational differences found by comparison with the DNA i-motif. The stacking topology of the main structure avoids one of the six 2'-OH/2'-OH repulsive contacts expected in a fully intercalated structure. The C3'-endo pucker of the RNA sugars and the orientation of the intercalated C.C+ pairs result in a modest widening of the narrow grooves at the steps where the hydroxyl groups are in close contact. The free energy of the RNA i-motif, on average -4 kJ mol(-1) per C.C+ pair, is half of the value found in DNA i-motif structures.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11491284}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11491284 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11491284}}
==About this Structure==
==About this Structure==
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9K OCA].
+
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9K OCA].
==Reference==
==Reference==
Line 26: Line 30:
[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Rna]]
[[Category: Rna]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:44:33 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:37:56 2008''

Revision as of 07:37, 1 July 2008

Image:1i9k.png

Template:STRUCTURE 1i9k

THE RNA I-MOTIF

Template:ABSTRACT PUBMED 11491284

About this Structure

Full experimental information is available from OCA.

Reference

The RNA i-motif., Snoussi K, Nonin-Lecomte S, Leroy JL, J Mol Biol. 2001 May 25;309(1):139-53. PMID:11491284

Page seeded by OCA on Tue Jul 1 10:37:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i9k"
Personal tools