1ia0

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{{Seed}}
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{{STRUCTURE_1ia0| PDB=1ia0 | SCENE= }}
{{STRUCTURE_1ia0| PDB=1ia0 | SCENE= }}
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'''KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM'''
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===KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM===
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==Overview==
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Kinesin motors are specialized enzymes that use hydrolysis of ATP to generate force and movement along their cellular tracks, the microtubules. Although numerous biochemical and biophysical studies have accumulated much data that link microtubule-assisted ATP hydrolysis to kinesin motion, the structural view of kinesin movement remains unclear. This study of the monomeric kinesin motor KIF1A combines X-ray crystallography and cryo-electron microscopy, and allows analysis of force-generating conformational changes at atomic resolution. The motor is revealed in its two functionally critical states-complexed with ADP and with a non-hydrolysable analogue of ATP. The conformational change observed between the ADP-bound and the ATP-like structures of the KIF1A catalytic core is modular, extends to all kinesins and is similar to the conformational change used by myosin motors and G proteins. Docking of the ADP-bound and ATP-like crystallographic models of KIF1A into the corresponding cryo-electron microscopy maps suggests a rationale for the plus-end directional bias associated with the kinesin catalytic core.
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The line below this paragraph, {{ABSTRACT_PUBMED_11373668}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11373668 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11373668}}
==About this Structure==
==About this Structure==
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[[Category: Microtubule]]
[[Category: Microtubule]]
[[Category: Tubulin]]
[[Category: Tubulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:45:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:38:54 2008''

Revision as of 07:38, 1 July 2008

Image:1ia0.png

Template:STRUCTURE 1ia0

KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM

Template:ABSTRACT PUBMED 11373668

About this Structure

1IA0 is a Protein complex structure of sequences from Mus musculus and Sus scrofa. Full crystallographic information is available from OCA.

Reference

Switch-based mechanism of kinesin motors., Kikkawa M, Sablin EP, Okada Y, Yajima H, Fletterick RJ, Hirokawa N, Nature. 2001 May 24;411(6836):439-45. PMID:11373668

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