1iak

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{{STRUCTURE_1iak| PDB=1iak | SCENE= }}
{{STRUCTURE_1iak| PDB=1iak | SCENE= }}
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'''HISTOCOMPATIBILITY ANTIGEN I-AK'''
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===HISTOCOMPATIBILITY ANTIGEN I-AK===
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==Overview==
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We have determined the structure of murine MHC class II I-Ak in complex with a naturally processed peptide from hen egg lysozyme (HEL residues 50-62) at 1.9 A resolution. These results provide a structural basis for the I-Ak peptide-binding motif. Binding is established by the deep burial of five anchor side chains into specific pockets of the I-Ak binding groove, with a zen-like fit of an aspartic acid in the P1 pocket. We also show that in the I-Ak alpha chain, a bulge occurs in the first strand of the peptide-binding platform, an insertion probably common to all I-A and HLA-DQ alleles. The I-Ak beta chain has a deletion in the helical region adjacent to the P7 pocket and an insertion in the helical region neighboring the P1 pocket. As a result of these structural features, the extended HEL peptide dips low into the center of the I-Ak groove and reaches toward solvent at its C-terminal end.
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(as it appears on PubMed at http://www.pubmed.gov), where 9529148 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9529148}}
==About this Structure==
==About this Structure==
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[[Category: Mhc]]
[[Category: Mhc]]
[[Category: Peptide complex]]
[[Category: Peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:40:16 2008''

Revision as of 07:40, 1 July 2008

Image:1iak.png

Template:STRUCTURE 1iak

HISTOCOMPATIBILITY ANTIGEN I-AK

Template:ABSTRACT PUBMED 9529148

About this Structure

1IAK is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of I-Ak in complex with a dominant epitope of lysozyme., Fremont DH, Monnaie D, Nelson CA, Hendrickson WA, Unanue ER, Immunity. 1998 Mar;8(3):305-17. PMID:9529148

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