This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1iar

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1iar.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1iar.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1iar| PDB=1iar | SCENE= }}
{{STRUCTURE_1iar| PDB=1iar | SCENE= }}
-
'''INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX'''
+
===INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX===
-
==Overview==
+
<!--
-
Interleukin-4 (IL-4) is a principal regulatory cytokine during an immune response and a crucial determinant for allergy and asthma. IL-4 binds with high affinity and specificity to the ectodomain of the IL-4 receptor alpha chain (IL4-BP). Subsequently, this intermediate complex recruits the common gamma chain (gamma c), thereby initiating transmembrane signaling. The crystal structure of the intermediate complex between human IL-4 and IL4-BP was determined at 2.3 A resolution. It reveals a novel spatial orientation of the two proteins, a small but unexpected conformational change in the receptor-bound IL-4, and an interface with three separate clusters of trans-interacting residues. Novel insights on ligand binding in the cytokine receptor family and a paradigm for receptors of IL-2, IL-7, IL-9, and IL-15, which all utilize gamma c, are provided.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10219247}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10219247 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10219247}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Sebald, W.]]
[[Category: Sebald, W.]]
[[Category: Cytokine receptor,interleukin-4]]
[[Category: Cytokine receptor,interleukin-4]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:46:54 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:40:51 2008''

Revision as of 07:40, 1 July 2008

Image:1iar.png

Template:STRUCTURE 1iar

INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX

Template:ABSTRACT PUBMED 10219247

About this Structure

1IAR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface., Hage T, Sebald W, Reinemer P, Cell. 1999 Apr 16;97(2):271-81. PMID:10219247

Page seeded by OCA on Tue Jul 1 10:40:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1iar"
Personal tools