1ias

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[[Image:1ias.gif|left|200px]]
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{{Seed}}
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[[Image:1ias.png|left|200px]]
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{{STRUCTURE_1ias| PDB=1ias | SCENE= }}
{{STRUCTURE_1ias| PDB=1ias | SCENE= }}
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'''CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12'''
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===CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12===
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==Overview==
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The type I TGF beta receptor (T beta R-I) is activated by phosphorylation of the GS region, a conserved juxtamembrane segment located just N-terminal to the kinase domain. We have studied the molecular mechanism of receptor activation using a homogeneously tetraphosphorylated form of T beta R-I, prepared using protein semisynthesis. Phosphorylation of the GS region dramatically enhances the specificity of T beta R-I for the critical C-terminal serines of Smad2. In addition, tetraphosphorylated T beta R-I is bound specifically by Smad2 in a phosphorylation-dependent manner and is no longer recognized by the inhibitory protein FKBP12. Thus, phosphorylation activates T beta R-I by switching the GS region from a binding site for an inhibitor into a binding surface for substrate. Our observations suggest that phosphoserine/phosphothreonine-dependent localization is a key feature of the T beta R-I/Smad activation process.
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The line below this paragraph, {{ABSTRACT_PUBMED_11583628}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11583628 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11583628}}
==About this Structure==
==About this Structure==
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[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Tgf-beta receptor]]
[[Category: Tgf-beta receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:46:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:40:57 2008''

Revision as of 07:41, 1 July 2008

Image:1ias.png

Template:STRUCTURE 1ias

CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12

Template:ABSTRACT PUBMED 11583628

About this Structure

1IAS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch., Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massague J, Mol Cell. 2001 Sep;8(3):671-82. PMID:11583628

Page seeded by OCA on Tue Jul 1 10:40:57 2008

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